Chit1^tm1Eli
Targeted Allele Detail

Summary

• Symbol: Chit1^tm1Eli
• Name: chitinase 1; targeted mutation 1, Jack A Elias
• MGI ID: MGI:5447948
• Gene: Chit1 Location: Chr1:134038980-134079278 bp, + strand Genetic Position: Chr1, 58.12 cM, cytoband E4
• Alliance: Chit1^tm1Eli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189872
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette replaced exons 1 through 5. ELISA confirmed the absence of protein expression in the serum. (J:189872)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chit1 Mutation: 32 strains or lines available

References

• Original: J:189872 Lee CG, et al., Chitinase 1 is a biomarker for and therapeutic target in scleroderma-associated interstitial lung disease that augments TGF-beta1 signaling. J Immunol. 2012 Sep 1;189(5):2635-44
• All: 2 reference(s)