Lef1^tm1Hhx
Targeted Allele Detail

Summary

• Symbol: Lef1^tm1Hhx
• Name: lymphoid enhancer binding factor 1; targeted mutation 1, Hai-Hui Xue
• MGI ID: MGI:5447957
• Synonyms: Lef1^FL
• Gene: Lef1 Location: Chr3:130904120-131018005 bp, + strand Genetic Position: Chr3, 60.78 cM
• Alliance: Lef1^tm1Hhx page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189838
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 7. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 8. Flp-mediated recombination removed the neo cassette and left exons 7 and 8 were floxed. (J:189838, J:190675)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Lef1 Mutation: 43 strains or lines available

References

• Original: J:189838 Zhou X, et al., Cutting edge: generation of memory precursors and functional memory CD8+ T cells depends on T cell factor-1 and lymphoid enhancer-binding factor-1. J Immunol. 2012 Sep 15;189(6):2722-6
• All: 24 reference(s)