Gt(ROSA)26Sor^{tm1(CAG-FOXO1,GFP)Moli}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-FOXO1,GFP)Moli}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Ming O Li
• MGI ID: MGI:5447989
• Synonyms: Foxo1^AAA, Gt(ROSA)26Sor^{tm1(CAG-FOXO1,-GFP)Moli}
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-FOXO1,GFP)Moli} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189962
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CAG-FOXO1,GFP)Moli} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  FOXO1 (2308)

  Foxo1

  (MGI:1890077)

• Mutation details: The targeting contruct inserted into intron 1 contained a CAG promoter, floxed neo/STOP cassette, HA-tagged human cDNA, an FRT-flanked IRES/EGFP and a polyadenylation sequence. (J:189962)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 991 strains or lines available

References

• Original: J:189962 Ouyang W, et al., Novel Foxo1-dependent transcriptional programs control T(reg) cell function. Nature. 2012 Nov 22;491(7425):554-9
• All: 16 reference(s)