Irx6^tm1Chow
Targeted Allele Detail

Summary

• Symbol: Irx6^tm1Chow
• Name: Iroquois homeobox 6; targeted mutation 1, Robert L Chow
• MGI ID: MGI:5448232
• Synonyms: Irx6^lacZ
• Gene: Irx6 Location: Chr8:93400917-93407584 bp, + strand Genetic Position: Chr8, 44.99 cM
• Alliance: Irx6^tm1Chow page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189955
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 and part of exon 2 were replaced with a lacZ neo cassette via homologous recombination. Scattered lacZ expression was detected throughout the embryo at E12.5. Onset and localization of lacZ expression is consistent with endogenous mRNA expression. (J:189955)

Expression

In Mice Carrying this Mutation:	96 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irx6 Mutation: 27 strains or lines available

References

• Original: J:189955 Star EN, et al., Regulation of retinal interneuron subtype identity by the Iroquois homeobox gene Irx6. Development. 2012 Dec;139(24):4644-55
• All: 1 reference(s)