Dppa3^tm1(rtTA)Nkn
Targeted Allele Detail

Summary

• Symbol: Dppa3^tm1(rtTA)Nkn
• Name: developmental pluripotency-associated 3; targeted mutation 1, Toru Nakano
• MGI ID: MGI:5448272
• Synonyms: Dppa3^tm1, PGC7 KO, Stella^-
• Gene: Dppa3 Location: Chr6:122603383-122607230 bp, + strand Genetic Position: Chr6, 57.72 cM
• Alliance: Dppa3^tm1(rtTA)Nkn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189990
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Transactivator)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The start codon was replaced with an rtTA cDNA and a floxed neo cassette via homologous recombination. (J:189990)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dppa3 Mutation: 24 strains or lines available

References

• Original: J:189990 Nakamura T, et al., PGC7/Stella protects against DNA demethylation in early embryogenesis. Nat Cell Biol. 2007 Jan;9(1):64-71
• All: 8 reference(s)