Mir122^tm1.1Kgh
Targeted Allele Detail

Summary

• Symbol: Mir122^tm1.1Kgh
• Name: microRNA 122; targeted mutation 1.1, Kalpana Ghoshal
• MGI ID: MGI:5448467
• Gene: Mir122 Location: Chr18:65381932-65381997 bp, + strand
• Alliance: Mir122^tm1.1Kgh page

Mir122^tm1.1Kgh/Mir122^tm1.1Kgh mice develop hepatitis and fibrosis with age

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:190067
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Cre-mediated recombination removed the microRNA sequence. The FRT-flanked neo cassette remains intact. (J:190067)

Generation of the Mir122^tm1.2Kgh and Mir122^tm1.1Kgh alleles

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir122 Mutation: 9 strains or lines available

References

• Original: J:190067 Hsu SH, et al., Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver. J Clin Invest. 2012 Aug 1;122(8):2871-83
• All: 8 reference(s)