Mir122^tm1.1Apts
Targeted Allele Detail

Summary

• Symbol: Mir122^tm1.1Apts
• Name: microRNA 122; targeted mutation 1.1, Ann-Ping Tsou
• MGI ID: MGI:5448652
• Gene: Mir122 Location: Chr18:65381932-65381997 bp, + strand
• Alliance: Mir122^tm1.1Apts page

Liver tumor formation in Mir122^tm1.1Apts/Mir122^tm1.1Apts males

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:190066
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of the mircoRNA. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of the microRNA. Cre-mediated recombination removed the microRNA and the neo cassette. (J:190066)

Generation of the Mir122^tm1.1Apts allele

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir122 Mutation: 9 strains or lines available

References

• Original: J:190066 Tsai WC, et al., MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis. J Clin Invest. 2012 Aug 1;122(8):2884-97
• All: 4 reference(s)