Pank3^tm1.1Suja
Targeted Allele Detail

Summary

• Symbol: Pank3^tm1.1Suja
• Name: pantothenate kinase 3; targeted mutation 1.1, Suzanne Jackowski
• MGI ID: MGI:5448673
• Gene: Pank3 Location: Chr11:35660322-35682112 bp, + strand Genetic Position: Chr11, 21.96 cM
• Alliance: Pank3^tm1.1Suja page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189609
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A selection cassette containing cDNAs encoding thymidine kinase and neomycin resistance with a loxP site was inserted into the intron between exons 2 and 3. An additional loxP site was inserted between exons 3 and 4. Cre-mediated recombination removed exon 3 and the neo cassette. (J:189609)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pank3 Mutation: 21 strains or lines available

References

• Original: J:189609 Garcia M, et al., Germline deletion of pantothenate kinases 1 and 2 reveals the key roles for CoA in postnatal metabolism. PLoS One. 2012;7(7):e40871
• All: 1 reference(s)