Akap5^tm1Mdaq
Targeted Allele Detail

Summary

• Symbol: Akap5^tm1Mdaq
• Name: A kinase anchor protein 5; targeted mutation 1, Mark Dell'Acqua
• MGI ID: MGI:5448682
• Synonyms: AKAP150deltaPIX, Akap5^tm2Jsco
• Gene: Akap5 Location: Chr12:76371665-76380927 bp, + strand Genetic Position: Chr12, 33.73 cM
• Alliance: Akap5^tm1Mdaq page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:190017
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (C57BL/6 x 129)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The 21 bp sequence in the coding exon containing the conserved PIAIIIT motif (amino acids 655 to 661) was removed. A floxed neo cassette was inserted downstream of the modified coding exon. (J:190017)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Akap5 Mutation: 27 strains or lines available

References

• Original: J:190017 Hinke SA, et al., Anchored phosphatases modulate glucose homeostasis. EMBO J. 2012 Oct 17;31(20):3991-4004
• All: 7 reference(s)