Kdm6a^tm1.2Kaig
Targeted Allele Detail

Summary

• Symbol: Kdm6a^tm1.2Kaig
• Name: lysine (K)-specific demethylase 6A; targeted mutation 1.2, Kai Ge
• MGI ID: MGI:5448825
• Synonyms: UTX^-
• Gene: Kdm6a Location: ChrX:18028814-18146175 bp, + strand Genetic Position: ChrX, 13.45 cM
• Alliance: Kdm6a^tm1.2Kaig page

Neural tube closure, cardiac development and hematopoiesis defects in Kdm6a^tm1.2Kaig/Kdm6a^tm1.2Kaig females

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:190157
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Cre-mediated recombination removed the modified exon 24. Western blot analysis confirmed the absence of protein expression in embryonic stem cells. (J:190157)

Generation of the Kdm6a^tm1.2Kaig allele

Expression

In Mice Carrying this Mutation:	10 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdm6a Mutation: 40 strains or lines available

References

• Original: J:190157 Wang C, et al., UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15324-9
• All: 1 reference(s)