Kdm6a^tm2.1Kaig
Targeted Allele Detail

Summary

• Symbol: Kdm6a^tm2.1Kaig
• Name: lysine (K)-specific demethylase 6A; targeted mutation 2.1, Kai Ge
• MGI ID: MGI:5448826
• Synonyms: UTX^KI
• Gene: Kdm6a Location: ChrX:18028814-18146175 bp, + strand Genetic Position: ChrX, 13.45 cM
• Alliance: Kdm6a^tm2.1Kaig page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:232700
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 24 was replaced with a loxP site flanked modified exon 24 in which nulceotide substitutions result in the amino acid substitution of histidine with alanine and glutamic acid at positions 1146 and 1148 (H1146A and E1148A). Flp-mediated recombination removed the FRT site flanked neomycin resistance gene cassette inserted downstream of the modified exon 24. The modified exon 24 remains floxed. (J:190157)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdm6a Mutation: 40 strains or lines available

References

• Original: J:232700 Faralli H, et al., UTX demethylase activity is required for satellite cell-mediated muscle regeneration. J Clin Invest. 2016 Apr 1;126(4):1555-65
• All: 5 reference(s)