Mir378a^tm1.1Eno
Targeted Allele Detail

Summary

• Symbol: Mir378a^tm1.1Eno
• Name: microRNA 378a; targeted mutation 1.1, Eric N Olson
• MGI ID: MGI:5448834
• Gene: Mir378a Location: Chr18:61530906-61530971 bp, - strand Genetic Position: Chr18, 34.62 cM
• Alliance: Mir378a^tm1.1Eno page

Mir378a^tm1.1Eno/Mir378a^tm1.1Eno mice are resistant to high-fat diet-induced obesity

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:190154
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: The microRNA sequence was replaced with a floxed neo cassette. Cre-mediated recombination removed the neo cassette. qRT-PCR confirmed the absence of transcript expression. Western blot analysis confirmed normal protein expression of the host gene. (J:190154)

Generation of the Mir378a^tm1.1Eno allele

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir378a Mutation: 5 strains or lines available

References

• Original: J:190154 Carrer M, et al., Control of mitochondrial metabolism and systemic energy homeostasis by microRNAs 378 and 378*. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15330-5
• All: 6 reference(s)