Rictor^tm1.1Klg
Targeted Allele Detail

Summary

• Symbol: Rictor^tm1.1Klg
• Name: RPTOR independent companion of MTOR, complex 2; targeted mutation 1.1, Kun-Liang Guan
• MGI ID: MGI:5448837
• Synonyms: Rictor^F
• Gene: Rictor Location: Chr15:6737860-6829882 bp, + strand Genetic Position: Chr15, 3.25 cM, cytoband A1
• Alliance: Rictor^tm1.1Klg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189736
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a loxP site followed by a frt-flanked neomycin resistance (neo) cassette upstream of exon 11, and a second loxP site downstream of exon 11. Flp-mediated recombination removed the neo cassette and left exon 11 floxed. (J:189736, J:191342)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Rictor Mutation: 141 strains or lines available

References

• Original: J:189736 Tang F, et al., A critical role for Rictor in T lymphopoiesis. J Immunol. 2012 Aug 15;189(4):1850-7
• All: 59 reference(s)