Tg(Krt18-EGFP,-TAg121)36Ysng
Transgene Detail

Summary

• Symbol: Tg(Krt18-EGFP,-TAg121)36Ysng
• Name: transgene insertion 36, Yurong Song
• MGI ID: MGI:5449063
• Synonyms: TgK18GT121, TgK18GT121-36, TgK18GT121 Line 36, TgK18GT121^tg, Tg(K18GT121)Tvd
• Transgene: Tg(Krt18-EGFP,-TAg121)36Ysng Location: unknown
• Alliance: Tg(Krt18-EGFP,-TAg121)36Ysng page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: Mice from this transgenic line carry a bacterial artificial chromosome (BAC) containing the mouse keratin 18 gene, into which a loxP-GFP-stop-loxP (LSL) T121 (the N-terminal domain of SV40 large T antigen) cassette was inserted. This line exibits epithelial-specific Cre-dependent expression of T121 to dominantly interfere with all 3 pocket proteins (pRB, p107, and p130), facilitating RB-TS inactivation in vivo with a single construct. One copy of the transgene was observed in mice from line 36. (J:221017)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Krt18-EGFP,-TAg121)36Ysng

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:189304 Szabova L, et al., Perturbation of Rb, p53, and Brca1 or Brca2 cooperate in inducing metastatic serous epithelial ovarian cancer. Cancer Res. 2012 Aug 15;72(16):4141-53
• All: 6 reference(s)