Epcam^tm1Hmd
Targeted Allele Detail

Summary

• Symbol: Epcam^tm1Hmd
• Name: epithelial cell adhesion molecule; targeted mutation 1, Hiroshi Hamada
• MGI ID: MGI:5449520
• Synonyms: EpCAM^betageo
• Gene: Epcam Location: Chr17:87943407-87958555 bp, + strand Genetic Position: Chr17, 57.87 cM
• Alliance: Epcam^tm1Hmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:190580
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: An FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 3. Western blot analysis confirmed the absence of protein expression in the intestine. (J:190580)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Epcam Mutation: 33 strains or lines available

References

• Original: J:190580 Lei Z, et al., EpCAM contributes to formation of functional tight junction in the intestinal epithelium by recruiting claudin proteins. Dev Biol. 2012 Nov 15;371(2):136-45
• All: 1 reference(s)