Epcam^tm1.2Hmd
Targeted Allele Detail

Summary

• Symbol: Epcam^tm1.2Hmd
• Name: epithelial cell adhesion molecule; targeted mutation 1.2, Hiroshi Hamada
• MGI ID: MGI:5449522
• Gene: Epcam Location: Chr17:87943407-87958555 bp, + strand Genetic Position: Chr17, 57.87 cM
• Alliance: Epcam^tm1.2Hmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:190580
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed the beta-geo cassette and exons 2 and 3. Western blot analysis confirmed the absence of protein expression in the intestine. (J:190580)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Epcam Mutation: 33 strains or lines available

References

• Original: J:190580 Lei Z, et al., EpCAM contributes to formation of functional tight junction in the intestinal epithelium by recruiting claudin proteins. Dev Biol. 2012 Nov 15;371(2):136-45
• All: 1 reference(s)