Dck^tm1.2Radu
Targeted Allele Detail

Summary

• Symbol: Dck^tm1.2Radu
• Name: deoxycytidine kinase; targeted mutation 1.2, Caius G Radu
• MGI ID: MGI:5449592
• Synonyms: Dck^flox
• Gene: Dck Location: Chr5:88912872-88931136 bp, + strand Genetic Position: Chr5, 43.96 cM, cytoband E2
• Alliance: Dck^tm1.2Radu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158373
• Parent Cell Line: LW1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a loxP sites flanking exon 3, followed by a frt-flanked neomycin resistance (neo) cassette. Flp-mediated recombination remvoed the neo cassette and left exon 3 floxed. (J:158373)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dck Mutation: 20 strains or lines available

References

• Original: J:158373 Toy G, et al., Requirement for deoxycytidine kinase in T and B lymphocyte development. Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5551-6
• All: 2 reference(s)