Pdcd1^tm1.1Liux
Targeted Allele Detail

Summary

• Symbol: Pdcd1^tm1.1Liux
• Name: programmed cell death 1; targeted mutation 1.1, Xiaolong Liu
• MGI ID: MGI:5449635
• Synonyms: Pdcd1^KI
• Gene: Pdcd1 Location: Chr1:93966027-93980278 bp, - strand Genetic Position: Chr1, 47.47 cM
• Alliance: Pdcd1^tm1.1Liux page

Decreased tumor growth in Pdcd1^tm1.1Liux/Pdcd1^tm1.1Liux mice following carcinoma cell inoculation

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:190150
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted Mutations: Insertion, Nucleotide substitutions Mutation details: Nucleotide substitutions (CCTAGTAC to TATGCGAC) disrupts the AP-1-binding site D of the proximal conserved region. Cre-mediated recombination removed the floxed neo cassette inserted downstream of the mutation site. (J:190150)

Generation of the Pdcd1^tm1.1Liux allele

Tumor Data

List all tumor models in MMHCdb carrying Pdcd1^tm1.1Liux

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdcd1 Mutation: 97 strains or lines available

References

• Original: J:190150 Xiao G, et al., Activator protein 1 suppresses antitumor T-cell function via the induction of programmed death 1. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15419-24
• All: 2 reference(s)