Il2^tm1.1Kasm
Targeted Allele Detail

Summary

• Symbol: Il2^tm1.1Kasm
• Name: interleukin 2; targeted mutation 1.1, Kendall A Smith
• MGI ID: MGI:5449713
• Gene: Il2 Location: Chr3:37174862-37180103 bp, - strand Genetic Position: Chr3, 18.3 cM, cytoband B-C
• Alliance: Il2^tm1.1Kasm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:190168
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: One loxP site was placed upstream of exon 1 while an FRT/loxP flanked neomycin cassette was inserted in intron 2. Correctly targeted mice were mated with flp recombinase expressing mice to excise the neo selection cassette leaving exons 1 and 2 flanked by loxP sites. The flp expressing transgene was then bred away. (J:190168)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il2 Mutation: 43 strains or lines available

References

• Original: J:190168 Popmihajlov Z, et al., Conditional IL-2 Gene Deletion: Consequences for T Cell Proliferation. Front Immunol. 2012;3:102
• All: 6 reference(s)