Tg(Neurog3-cre/ERT2)1Able
Transgene Detail

Summary

• Symbol: Tg(Neurog3-cre/ERT2)1Able
• Name: transgene insertion 1, Andrew B Leiter
• MGI ID: MGI:5449724
• Synonyms: Ngn3-Cre/ERT2
• Transgene: Tg(Neurog3-cre/ERT2)1Able Location: unknown
• Alliance: Tg(Neurog3-cre/ERT2)1Able page

Transgene origin

• Strain of Origin: C57BL/6 x (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Neurog3-cre/ERT2)1Able expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Neurog3

• Mutation details: Homologous recombination inserted the cre recombinase sequence fused to a mutated tamoxifen-inducible estrogen receptor (cre/ERT2) into the translation initiation ATG codon of the neurogenin 3 gene located in a BAC. Three founder lines were obtained which all produced nearly identical patterns of cre expression. A generic line 1 was created as representative. (J:190530)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Neurog3 (species not specified) Summary of all recombinase alleles driven by Neurog3. Comparative matrix view of recombinase activities

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:190530 Li HJ, et al., Notch signaling differentially regulates the cell fate of early endocrine precursor cells and their maturing descendants in the mouse pancreas and intestine. Dev Biol. 2012 Nov 15;371(2):156-69
• All: 5 reference(s)