Bcl6^tm1.1Jwan
Targeted Allele Detail

Summary

• Symbol: Bcl6^tm1.1Jwan
• Name: B cell leukemia/lymphoma 6; targeted mutation 1.1, Jing H Wang
• MGI ID: MGI:5449732
• Synonyms: Bcl6^Sgamma1
• Gene: Bcl6 Location: Chr16:23783802-23807602 bp, - strand Genetic Position: Chr16, 15.26 cM
• Alliance: Bcl6^tm1.1Jwan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:190534
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A 4 kb segment of an endogenous core Sgamma1 region (a non-immune target of somatic hypermutation) was inserted into intron 1. Cre-mediated recombination removed the floxed neo cassette inserted upstream of the core Sgamma1 region. (J:190534)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl6 Mutation: 57 strains or lines available

References

• Original: J:190534 Chen Z, et al., Target DNA sequence directly regulates the frequency of activation-induced deaminase-dependent mutations. J Immunol. 2012 Oct 15;189(8):3970-82
• All: 1 reference(s)