Six1^tm2.1Mair
Targeted Allele Detail

Summary

• Symbol: Six1^tm2.1Mair
• Name: sine oculis-related homeobox 1; targeted mutation 2.1, Pascal Maire
• MGI ID: MGI:5449750
• Synonyms: Six1^flox
• Gene: Six1 Location: Chr12:73088601-73093486 bp, - strand Genetic Position: Chr12, 30.34 cM
• Alliance: Six1^tm2.1Mair page

Impaired tissue repair in regenerated Six1^tm2.1Mair/Six1^tm2.1Mair Pax7^{tm1(cre/ERT2)Gaka}/Pax7⁺ muscles

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:190460
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted into the 5' end of exon 1. An FRT-flanked neo cassette with a 3' loxP site and downstream dsRed gene was inserted downstream of exon 1. Flp-mediated recombination removed the neo cassette and left exon 1 floxed. (J:190460)

Generation of the conditional Six1^tm2.1Mair and delta Six1^tm2.2Mair alleles

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Six1^tm2.1Mair

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Six1 Mutation: 19 strains or lines available

References

• Original: J:190460 Le Grand F, et al., Six1 regulates stem cell repair potential and self-renewal during skeletal muscle regeneration. J Cell Biol. 2012 Sep 3;198(5):815-32
• All: 11 reference(s)