Tg(SOD1*A4V)A1073Gur
Transgene Detail

Summary

• Symbol: Tg(SOD1*A4V)A1073Gur
• Name: transgene insertion A1073, Mark E Gurney
• MGI ID: MGI:5449884
• Synonyms: A4V
• Transgene: Tg(SOD1*A4V)A1073Gur Location: unknown
• Alliance: Tg(SOD1*A4V)A1073Gur page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(SOD1*A4V)A1073Gur expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SOD1 (6647)

  Sod1	(MGI:98351)

• Mutation details: This transgene construct consists of the human SOD1 gene with an alanine to valine substitution at position 4 (A4V) in exon 1. Northern and Western analysis confirmed RNA and protein expression in the brain. This mutation alters the activity of the protein and mice show greatly reduced enzymatic activity. Two lines were made, A1073 and A1074. (J:32665)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:32665 Gurney ME, et al., Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation [see comments] [published erratum appears in Science 1995 Jul 14;269(5221):149]. Science. 1994 Jun 17;264(5166):1772-5
• All: 2 reference(s)