Del(7Cyp2s1-Cyp2a5)1Ding
Targeted Allele Detail

Summary

• Symbol: Del(7Cyp2s1-Cyp2a5)1Ding
• Name: deletion, Chr 7, Xinxin Ding 1
• MGI ID: MGI:5449923
• Synonyms: Cyp2a(4/5)bgs null
• Gene: Del(7Cyp2s1-Cyp2a5)1Ding Location: Chr7:25501901-26542689 bp Genetic Position: Chr7, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:190445
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Del(7Cyp2s1-Cyp2a5)1Ding involves 28 genes/genome features (Gm24865, Cyp2b19-ps, Gm25947 ...) View all
• Mutation details: Cre mediated recombination between Cyp2s1^tm1Ding and Cyp2a5^tm1Ding removed a 1.2 megabase region. This region contains 9 Cyp genes that correspond to the human CYP2 gene cluster located on chromosome 19. PCR analysis confirms the absence of expression of multiple Cyp genes. (J:190445)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(7Cyp2s1-Cyp2a5)1Ding Mutation: 0 strains or lines available

References

• Original: J:190445 Wei Y, et al., Generation and Characterization of a Novel Cyp2a(4/5)bgs-Null Mouse Model. Drug Metab Dispos. 2013 Jan;41(1):132-40
• All: 2 reference(s)