Gt(ROSA)26Sor^{tm4(CAG-EGFP*)Nat}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm4(CAG-EGFP*)Nat}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 4, Jeremy Nathans
• MGI ID: MGI:5449932
• Synonyms: Gt(ROSA)26^{tm1(CAG-LSL-MitoGFP-3xV5)Nat}, mitoEGFP
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm4(CAG-EGFP*)Nat} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: A targeting vector containing (from 5' to 3') a CAG promoter, a loxP-flanked transcription STOP cassette, the N-terminal 25 amino acid mitochondrial-targeting sequence of cytochrome c oxidase VIIIa (C8a), EGFP fused to a C-terminal triple V5 epitope, a bovine growth hormone 3' UTR, and a Frt-PGKneo-Frt cassette was inserted into the locus. (J:254093)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:254093 Agarwal A, et al., Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes. Neuron. 2017 Feb 8;93(3):587-605.e7
• All: 3 reference(s)