Il10ra^tm1.1Tlg
Targeted Allele Detail

Summary

• Symbol: Il10ra^tm1.1Tlg
• Name: interleukin 10 receptor, alpha; targeted mutation 1.1, Terrence L Geiger
• MGI ID: MGI:5450726
• Synonyms: IL-10Ralpha^fl
• Gene: Il10ra Location: Chr9:45165135-45180447 bp, - strand Genetic Position: Chr9, 24.84 cM
• Alliance: Il10ra^tm1.1Tlg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189797
• Parent Cell Line: V26.2 (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT flanked PGK neo resistance cassette was inserted in intron 2 and loxP sites were inserted flanking exon 3. Subsequent expression of flp recombinase removed the selection cassette leaving exon 3 flanked by loxP sites. Exon 3 contains much of the Il10 interacting domain. Genomic loss of exon 3 was observed in T cells expressing cre under the control of the Cd4 promoter by PCR analysis. (J:189797)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il10ra Mutation: 32 strains or lines available

References

• Original: J:189797 Liu X, et al., The T cell response to IL-10 alters cellular dynamics and paradoxically promotes central nervous system autoimmunity. J Immunol. 2012 Jul 15;189(2):669-78
• All: 10 reference(s)