Serpina3g^tm1.1Arp
Targeted Allele Detail

Summary

• Symbol: Serpina3g^tm1.1Arp
• Name: serine (or cysteine) peptidase inhibitor, clade A, member 3G; targeted mutation 1.1, Philip Ashton-Rickardt
• MGI ID: MGI:5450829
• Synonyms: Serpina3g^delta, Serpina3g^tm1.1Dowo
• Gene: Serpina3g Location: Chr12:104202504-104208198 bp, + strand Genetic Position: Chr12, 53.71 cM, cytoband F1
• Alliance: Serpina3g^tm1.1Arp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189782
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 4. A floxed neo cassette was inserted downstream of exon 4. Cre-mediated recombination removed exon 4 and the neo cassette. Experiments confirmed the absence of transcript expression in splenocytes. (J:195889)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Serpina3g Mutation: 26 strains or lines available

Notes

ES cell line = PRX-B6tN-1 (C57BL/6J).

References

• Original: J:189782 Byrne SM, et al., Cathepsin B controls the persistence of memory CD8+ T lymphocytes. J Immunol. 2012 Aug 1;189(3):1133-43
• All: 2 reference(s)