Rest^tm1.2Yasu
Targeted Allele Detail

Summary

• Symbol: Rest^tm1.2Yasu
• Name: RE1-silencing transcription factor; targeted mutation 1.2, Yasuhiro Yamada
• MGI ID: MGI:5450876
• Gene: Rest Location: Chr5:77413338-77434279 bp, + strand Genetic Position: Chr5, 41.61 cM
• Alliance: Rest^tm1.2Yasu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:190948
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4 was replaced with a construct containing the following elements: loxP site, exon 4, IRES, GFP, loxP, neo cassette, and loxP site. Cre mediated recombination removed the neo cassette, exon 4 and the GFP gene. (J:157076)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rest Mutation: 96 strains or lines available

References

• Original: J:190948 Okamura D, et al., REST and its downstream molecule Mek5 regulate survival of primordial germ cells. Dev Biol. 2012 Dec 15;372(2):190-202
• All: 2 reference(s)