Dp(17Nfkbil1-Or2h1)1Cogr
Targeted Allele Detail

Summary

• Symbol: Dp(17Nfkbil1-Or2h1)1Cogr
• Name: duplication, Chr 17, Cornelius Gross 1
• MGI ID: MGI:5451036
• Synonyms: Dp(17)1Cogr, Dp(17Nfkbil1-Olfr91)1Cogr, Dp(MHC-I)
• Gene: Dp(17Nfkbil1-Or2h1)1Cogr Location: Chr17:35439151-37409170 bp Genetic Position: Chr17, Syntenic

Decreased susceptibility to atherosclerosis in Apoe^tm1Unc/Apoe^tm1Unc Dp(17Nfkbil1-Or2h1)1Cogr/0 mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:190754
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

Allele Type: Targeted (Not Applicable) Mutations: Duplication, Insertion Dp(17Nfkbil1-Or2h1)1Cogr involves 166 genes/genome features (Gm20527, Gm19645, Gm17414 ...) View all Mutation details: Cre-mediated recombination of MICER clones (MHPP188d21 and MHPN390j16), which contain loxP site upstream of Nfkbil1 and downstream of Olfr91, results in the duplication of the 1.9 Mb between and including the two genes. This duplication contains the class I major histocompatibility locus. (J:190754)

Engineering of the Dp(17Nfkbil1-Or2h1)1Cogr duplication

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dp(17Nfkbil1-Or2h1)1Cogr Mutation: 1 strain or line available

References

• Original: J:190754 Ermakova O, et al., Construction and phenotypic analysis of mice carrying a duplication of the major histocompatibility class I (MHC-I) locus. Mamm Genome. 2012 Aug;23(7-8):443-53
• All: 1 reference(s)