Mirc33^tm1.1Cwh
Targeted Allele Detail

Summary

• Symbol: Mirc33^tm1.1Cwh
• Name: microRNA cluster 33, including Mir29a through Mir29b-1; targeted mutation 1.1, Caroline C Whitacre
• MGI ID: MGI:5451057
• Synonyms: miR-29ab1^-, Mir29a/Mir29b-1^tm1.1Cwh
• Gene: Mirc33 Location: Chr6:31039595-31040028 bp Genetic Position: Chr6, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189763
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: MicroRNAs Mir29a and Mir29b-1 were floxed and an FRT-flanked neo cassette was inserted downstream of the microRNAs. Cre-mediated recombination removed the microRNA sequences. (J:189763)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mirc33 Mutation: 0 strains or lines available

References

• Original: J:189763 Smith KM, et al., miR-29ab1 deficiency identifies a negative feedback loop controlling Th1 bias that is dysregulated in multiple sclerosis. J Immunol. 2012 Aug 15;189(4):1567-76
• All: 5 reference(s)