Tg(Hexb-tTA2S,tetO-Hexb)#Tjsa
Transgene Detail

Summary

• Symbol: Tg(Hexb-tTA2S,tetO-Hexb)#Tjsa
• Name: transgene insertion, Timothy J Sargeant
• MGI ID: MGI:5451190
• Synonyms: Hex^Tg, P8Hex (+)
• Transgene: Tg(Hexb-tTA2S,tetO-Hexb)#Tjsa Location: unknown
• Alliance: Tg(Hexb-tTA2S,tetO-Hexb)#Tjsa page

Localized glycolipid storage and microgliosis in Hexb^tm1Rlp/Hexb^tm1Rlp Tg(Hexb-tTA2S,tetO-Hexb)#Tjsa/0 mice

Show the 3 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: C57BL/6 x CBA

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence, Transactivator)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(Hexb-tTA2S,tetO-Hexb)#Tjsa expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Hexb (MGI:96074)

• Mutation details: The proximal murine Hexb promoter (330 bp) drives expression of the tet-transactivator from the pTet-off advanced plasmid and tet responsive element (TRE-tight) drives expression of a full-length mouse Hexb cDNA. Expression is seen only in the nervous tissue, skin, and skeletal muscle. In the cerebral cortex expression of the tet-transactivator transcript is evenly distributed through the cortex. (J:190450)

Schematic of the Tg(Hexb-tTA2S,tetO-Hexb)#Tjsa transgene construct

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:190450 Sargeant TJ, et al., Characterization of inducible models of Tay-Sachs and related disease. PLoS Genet. 2012 Sep;8(9):e1002943
• All: 1 reference(s)