Tg(SYN1-tTA2S,tetO-Hexb)#Tjsa
Transgene Detail

Summary

• Symbol: Tg(SYN1-tTA2S,tetO-Hexb)#Tjsa
• Name: transgene insertion, Timothy J Sargeant
• MGI ID: MGI:5451192
• Synonyms: P8SYN (+), SYN^Tg
• Transgene: Tg(SYN1-tTA2S,tetO-Hexb)#Tjsa Location: unknown
• Alliance: Tg(SYN1-tTA2S,tetO-Hexb)#Tjsa page

Doxycycline treatment of Hexb^tm1Rlp/Hexb^tm1Rlp Tg(Hexb-tTA2S,tetO-Hexb)#Tjsa/0 and Hexb^tm1Rlp/Hexb^tm1Rlp Tg(SYN1-tTA2S,tetO-Hexb)#Tjsa/0 mice induces storage of glycolipids

Show the 2 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: C57BL/6 x CBA

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence, Transactivator)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(SYN1-tTA2S,tetO-Hexb)#Tjsa expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Hexb (MGI:96074)

• Mutation details: The human SYN1 promoter drives expression of the tet-transactivator from the pTet-off advanced plasmid and tet responsive element (TRE-tight) drives expression of a full lenght mouse Hexb cDNA. Expression is seen only in the nervous tissue. In the cerebral cortex, the tet-transactivator transcript is strongly expressed in layer 6b neurons. (J:190450)

Schematic of the Tg(SYN1-tTA2S,tetO-Hexb)#Tjsa transgene construct

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:190450 Sargeant TJ, et al., Characterization of inducible models of Tay-Sachs and related disease. PLoS Genet. 2012 Sep;8(9):e1002943
• All: 1 reference(s)