Calca^{tm1.1(cre/ERT2)Ptch}
Targeted Allele Detail

Summary

• Symbol: Calca^{tm1.1(cre/ERT2)Ptch}
• Name: calcitonin/calcitonin-related polypeptide, alpha; targeted mutation 1.1, Pao-Tien Chuang
• MGI ID: MGI:5460801
• Synonyms: CGRP^CreER
• Gene: Calca Location: Chr7:114230713-114235592 bp, - strand Genetic Position: Chr7, 59.99 cM
• Alliance: Calca^{tm1.1(cre/ERT2)Ptch} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:190366
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Calca^{tm1.1(cre/ERT2)Ptch} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Calca (MGI:2151253)

• Mutation details: A cre/ERT2 fusion construct followed by an FRT flanked PGK neo selection cassette was inserted into exon 2 at the ATG translational start site. The selection cassette was subsequently removed by crossing properly targeted mice to mice expressing flp recombinase. (J:190366)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Calca (mouse) Summary of all recombinase alleles driven by Calca. Comparative matrix view of recombinase activities Alliance mouse Calca gene page

Tumor Data

List all tumor models in MMHCdb carrying Calca^{tm1.1(cre/ERT2)Ptch}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Calca Mutation: 23 strains or lines available

References

• Original: J:190366 Song H, et al., Functional characterization of pulmonary neuroendocrine cells in lung development, injury, and tumorigenesis. Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17531-6
• All: 24 reference(s)