Tg(Acta2-cre/ERT2)1Ikal
Transgene Detail

Summary

• Symbol: Tg(Acta2-cre/ERT2)1Ikal
• Name: transgene insertion 1, Ivo Kalajzic
• MGI ID: MGI:5461154
• Synonyms: alphaSMACreERT2
• Transgene: Tg(Acta2-cre/ERT2)1Ikal Location: unknown
• Alliance: Tg(Acta2-cre/ERT2)1Ikal page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Acta2-cre/ERT2)1Ikal expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Acta2

• Mutation details: The cre/ERT2 cDNA and BGH polyA cDNAs was inserted into a construct containing the vascular smooth muscle alpha-actin (Acta2) promoter. Functionality of the construct to modify floxed reporter constructs was tested by transient transfection of smooth muscle cell cultures. The purified vector was injected into fertilized C57BL/6 oocytes. (J:190191)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Acta2 (species not specified) Summary of all recombinase alleles driven by Acta2. Comparative matrix view of recombinase activities

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:190191 Grcevic D, et al., In vivo fate mapping identifies mesenchymal progenitor cells. Stem Cells. 2012 Feb;30(2):187-96
• All: 15 reference(s)