Men1^tm1Rvt
Targeted Allele Detail

Summary

• Symbol: Men1^tm1Rvt
• Name: multiple endocrine neoplasia 1; targeted mutation 1, Rajesh V Thakker
• MGI ID: MGI:5461232
• Gene: Men1 Location: Chr19:6385009-6390921 bp, + strand Genetic Position: Chr19, 4.45 cM, cytoband A
• Alliance: Men1^tm1Rvt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:191261
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A floxed neo cassette replaced exons 1 and 2. (J:191261)

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Men1^tm1Rvt

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Men1 Mutation: 40 strains or lines available

References

• Original: J:191261 Harding B, et al., Multiple endocrine neoplasia type 1 knockout mice develop parathyroid, pancreatic, pituitary and adrenal tumours with hypercalcaemia, hypophosphataemia and hypercorticosteronaemia. Endocr Relat Cancer. 2009 Dec;16(4):1313-27
• All: 6 reference(s)