Trem1^tm1.1Ahoru
Targeted Allele Detail

Summary

• Symbol: Trem1^tm1.1Ahoru
• Name: triggering receptor expressed on myeloid cells 1; targeted mutation 1.1, Anatolij Horuzsko
• MGI ID: MGI:5461334
• Synonyms: Trem1^tm1Mak
• Gene: Trem1 Location: Chr17:48539796-48553952 bp, + strand Genetic Position: Chr17, 23.99 cM
• Alliance: Trem1^tm1.1Ahoru page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:191035
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An EGFP and floxed neo cassette replaced exons 1 and 2. Cre-mediated recombination removed the neo cassette. (J:191035)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trem1 Mutation: 24 strains or lines available

References

• Original: J:191035 Wu J, et al., The proinflammatory myeloid cell receptor TREM-1 controls Kupffer cell activation and development of hepatocellular carcinoma. Cancer Res. 2012 Aug 15;72(16):3977-86
• All: 9 reference(s)