Stx11^tm1Bupa
Targeted Allele Detail

Summary

• Symbol: Stx11^tm1Bupa
• Name: syntaxin 11; targeted mutation 1, Silvia Bulfone-Paus
• MGI ID: MGI:5461477
• Gene: Stx11 Location: Chr10:12813953-12840042 bp, - strand Genetic Position: Chr10, 4.54 cM, cytoband A2
• Alliance: Stx11^tm1Bupa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:191103
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A PGK-neomycin selection cassette replaced the entire coding exon. (J:191103)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stx11 Mutation: 10 strains or lines available

References

• Original: J:191103 D'Orlando O, et al., Syntaxin 11 is required for NK and CD8(+) T-cell cytotoxicity and neutrophil degranulation. Eur J Immunol. 2013 Jan;43(1):194-208
• All: 3 reference(s)