Adcy3^tm1.1Hazh
Targeted Allele Detail

Summary

• Symbol: Adcy3^tm1.1Hazh
• Name: adenylate cyclase 3; targeted mutation 1.1, Haiqing Zhao
• MGI ID: MGI:5461479
• Synonyms: ACIII^S1076A
• Gene: Adcy3 Location: Chr12:4183397-4263525 bp, + strand Genetic Position: Chr12, 1.99 cM, cytoband A-B
• Alliance: Adcy3^tm1.1Hazh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:190988
• Parent Cell Line: MC1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Single point mutation
• Mutation details: Exon 21 was replaced with a modified one in which a T to G transition results in the amino acid substitution of alanine for serine at position 1076 (S1076A). A self-excising neo cassette inserted downstream of the modified exon was removed. (J:190988)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adcy3 Mutation: 43 strains or lines available

References

• Original: J:190988 Cygnar KD, et al., Phosphorylation of adenylyl cyclase III at serine1076 does not attenuate olfactory response in mice. J Neurosci. 2012 Oct 17;32(42):14557-62
• All: 1 reference(s)