Cerkl^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Cerkl^tm1.1Geno
• Name: ceramide kinase-like; targeted mutation 1.1, Genoway
• MGI ID: MGI:5461515
• Gene: Cerkl Location: Chr2:79162835-79259332 bp, - strand Genetic Position: Chr2, 47.43 cM
• Alliance: Cerkl^tm1.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:185135
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted usptream of exon 1. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 1. Cre-mediated recombination removed exon 1 and the neo cassette. Semi-quantitative RT-PCR confirmed reduced transcript expression in the retina, kidney, liver, spleen and testis. This allele is hypomorphic. (J:185135)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cerkl Mutation: 29 strains or lines available

References

• Original: J:185135 Garanto A, et al., Targeted knockdown of Cerkl, a retinal dystrophy gene, causes mild affectation of the retinal ganglion cell layer. Biochim Biophys Acta. 2012 Aug;1822(8):1258-69
• All: 6 reference(s)