Vdr^tm1.2Sgcg
Targeted Allele Detail

Summary

• Symbol: Vdr^tm1.2Sgcg
• Name: vitamin D (1,25-dihydroxyvitamin D3) receptor; targeted mutation 1.2, Songcang Chen
• MGI ID: MGI:5461525
• Gene: Vdr Location: Chr15:97752308-97806177 bp, - strand Genetic Position: Chr15, 53.85 cM
• Alliance: Vdr^tm1.2Sgcg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189471
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination of Vdr^tm1.1Sgcg, which lacks the neo cassette, removed exon 4. Western blot analysis confirmed the absence of protein expression in the tail. (J:189471)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vdr Mutation: 36 strains or lines available

References

• Original: J:189471 Chen S, et al., Cardiomyocyte-specific deletion of the vitamin D receptor gene results in cardiac hypertrophy. Circulation. 2011 Oct 25;124(17):1838-47
• All: 2 reference(s)