Cd28^tm1.1Huen
Targeted Allele Detail

Summary

• Symbol: Cd28^tm1.1Huen
• Name: CD28 antigen; targeted mutation 1.1, Thomas Hunig
• MGI ID: MGI:5461540
• Synonyms: Cd28^flox
• Gene: Cd28 Location: Chr1:60785547-60812521 bp, + strand Genetic Position: Chr1, 30.52 cM, cytoband C1-C3
• Alliance: Cd28^tm1.1Huen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:191101
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and a floxed neo cassette was inserted downstream of exon 3 via homologous recombination. Cre mediated recombination removed the neo cassette. (J:191101, J:264485)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd28 Mutation: 52 strains or lines available

References

• Original: J:191101 Gogishvili T, et al., Cell-intrinsic and -extrinsic control of Treg-cell homeostasis and function revealed by induced CD28 deletion. Eur J Immunol. 2013 Jan;43(1):188-93
• All: 6 reference(s)