Tg(Myh6-Erbb2)6Kaga
Transgene Detail

Summary

• Symbol: Tg(Myh6-Erbb2)6Kaga
• Name: transgene insertion 6, Kathleen Gabrielson
• MGI ID: MGI:5461578
• Synonyms: ErbB2^tg
• Transgene: Tg(Myh6-Erbb2)6Kaga Location: unknown
• Alliance: Tg(Myh6-Erbb2)6Kaga page

Transgene origin

• Strain of Origin: (C57BL/6J x SJL/J)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Erbb2)6Kaga expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Erbb2 (24337)

  Erbb2

  (MGI:95410)

• Mutation details: This transgene consists of the alpha-myosin heavy chain promoter driving the expression of the rat Erbb2 cDNA followed by a polyadenylation signal from human growth hormone. Two lines were made, 3 and 6. (J:189979)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:189979 Sysa-Shah P, et al., Cardiac-specific over-expression of epidermal growth factor receptor 2 (ErbB2) induces pro-survival pathways and hypertrophic cardiomyopathy in mice. PLoS One. 2012;7(8):e42805
• All: 5 reference(s)