Hdc^{tm1.1(icre)Wwis}
Targeted Allele Detail

Summary

• Symbol: Hdc^{tm1.1(icre)Wwis}
• Name: histidine decarboxylase; targeted mutation 1.1, William Wisden
• MGI ID: MGI:5461698
• Synonyms: HDC-Cre
• Gene: Hdc Location: Chr2:126435587-126461219 bp, - strand Genetic Position: Chr2, 61.76 cM, cytoband E5-G
• Alliance: Hdc^{tm1.1(icre)Wwis} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188103
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Hdc^{tm1.1(icre)Wwis} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Hdc (MGI:96062)

• Mutation details: A targeting vector was generated to insert an improved IRES2i site, a humanized cre open reading frame and an FRT-flanked neo selection cassette into exon 12 of histidine decarboxylase between the stop codon and polyadenylation sequence, by homologous recombination in ES cells. Chimeras were produced by ES cell injection into C57BL/6J blastocysts. The resulting line was bred with Flp deleter mice to remove the neo cassette. (J:188103)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Hdc (mouse) Summary of all recombinase alleles driven by Hdc. Comparative matrix view of recombinase activities Alliance mouse Hdc gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hdc Mutation: 53 strains or lines available

References

• Original: J:188103 Zecharia AY, et al., GABAergic inhibition of histaminergic neurons regulates active waking but not the sleep-wake switch or propofol-induced loss of consciousness. J Neurosci. 2012 Sep 19;32(38):13062-75
• All: 11 reference(s)