Tg(CAG-APPL1)#Ymli
Transgene Detail

Summary

• Symbol: Tg(CAG-APPL1)#Ymli
• Name: transgene insertion, Yiming Li
• MGI ID: MGI:5461701
• Synonyms: APPL1-Tg
• Transgene: Tg(CAG-APPL1)#Ymli Location: unknown
• Alliance: Tg(CAG-APPL1)#Ymli page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-APPL1)#Ymli expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APPL1 (26060)

  Appl1

  (MGI:1920243)

• Mutation details: The CAG promoter drives ubiquitous expression of a FLAG-tagged human cDNA. The pound symbol is used when no line is specified and/or lines are pooled. Increased expression is detected in mesenteric arteries, carotid arteries and aorta. (J:189487)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:189487 Wang Y, et al., APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice. Diabetes. 2011 Nov;60(11):3044-54
• All: 3 reference(s)