Tg(Pbsn-cre/Esr1*)14Abch
Transgene Detail

Summary

• Symbol: Tg(Pbsn-cre/Esr1*)14Abch
• Name: transgene insertion 14, Andreas Birbach
• MGI ID: MGI:5461708
• Synonyms: ProbasinBAC-MerCreMer
• Transgene: Tg(Pbsn-cre/Esr1*)14Abch Location: unknown
• Alliance: Tg(Pbsn-cre/Esr1*)14Abch page

Transgene origin

• Strain of Origin: C57BL/6NCrl

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Pbsn-cre/Esr1*)14Abch expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Pbsn (MGI:1860484)

• Mutation details: A BAC (#RP23-456A6; containing the entire mouse probasin (Pbsn) gene) was modified to insert a MerCreMer sequence (a double fusion of the cre recombinase cDNA sequence flanked on each end with a mutated murine estrogen receptor (mer) ligand-binding domain, resulting in tamoxifen-inducible cre expression) driven by the Pbsn promoter/enhancer region. The construct was microinjected into fertilized C57BL/6NCrl oocytes. Founder line 14 was established by breeding the founder, carrying 8-11 copies of the transgene, to wild-type C57BL/6J mice. (J:154786)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pbsn (mouse) Summary of all recombinase alleles driven by Pbsn. Alliance mouse Pbsn gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:154786 Birbach A, et al., A Probasin-MerCreMer BAC allows inducible recombination in the mouse prostate. Genesis. 2009 Nov;47(11):757-64
• All: 2 reference(s)