Frmpd4^tm1.1Pfw
Targeted Allele Detail

Summary

• Symbol: Frmpd4^tm1.1Pfw
• Name: FERM and PDZ domain containing 4; targeted mutation 1.1, Paul Worley
• MGI ID: MGI:5461737
• Gene: Frmpd4 Location: ChrX:166254305-167360227 bp, - strand Genetic Position: ChrX, 78.36 cM
• Alliance: Frmpd4^tm1.1Pfw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:191366
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 3. Cre-mediated recombination removed exon 3 and the neo cassette. Western blot analysis confirmed the absences of protein expression in the brain. (J:191366)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Frmpd4 Mutation: 16 strains or lines available

References

• Original: J:191366 Hu JH, et al., Preso1 dynamically regulates group I metabotropic glutamate receptors. Nat Neurosci. 2012 Jun;15(6):836-44
• All: 2 reference(s)