Ano1^tm1.1Jwo
Targeted Allele Detail

Summary

• Symbol: Ano1^tm1.1Jwo
• Name: anoctamin 1, calcium activated chloride channel; targeted mutation 1.1, John N Wood
• MGI ID: MGI:5461852
• Synonyms: Ano1^loxP
• Gene: Ano1 Location: Chr7:144142286-144305711 bp, - strand Genetic Position: Chr7, 88.85 cM
• Alliance: Ano1^tm1.1Jwo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:191353
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 8. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 8. Flp-mediated recombination removed the neo cassette and left exon 8 floxed. (J:191353)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ano1 Mutation: 60 strains or lines available

References

• Original: J:191353 Cho H, et al., The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons. Nat Neurosci. 2012 Jul;15(7):1015-21
• All: 6 reference(s)