Nodal^tm1.1Ysa
Targeted Allele Detail

Summary

• Symbol: Nodal^tm1.1Ysa
• Name: nodal growth differentiation factor; targeted mutation 1.1, Yumiko Saga
• MGI ID: MGI:5462059
• Synonyms: Nodal^flox
• Gene: Nodal Location: Chr10:61253751-61261117 bp, + strand Genetic Position: Chr10, 32.21 cM
• Alliance: Nodal^tm1.1Ysa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:191052
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted in intron 1 and an FRT flanked Betageo cassette and loxP site were inserted in the 3' untranslated region via homologous recombination. Flp mediated recombination removed the Betageo cassette leaving exons 2 and 3 floxed. (J:191052)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nodal Mutation: 42 strains or lines available

References

• Original: J:191052 Wu Q, et al., Nodal/activin signaling promotes male germ cell fate and suppresses female programming in somatic cells. Development. 2013 Jan;140(2):291-300
• All: 2 reference(s)