Stk39^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Stk39^tm1.1Arte
• Name: serine/threonine kinase 39; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:5462098
• Synonyms: SPAK^243A
• Gene: Stk39 Location: Chr2:68040789-68302381 bp, - strand Genetic Position: Chr2, 39.53 cM, cytoband C3
• Alliance: Stk39^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:191566
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEvBrd

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Single point mutation
• Mutation details: Exon 6 was replaced with an FRT-flanked neo cassette and a modified exon 6 in which an A to G transition results in the amino acid substitution of alanine for threonine at position 243 (T243A). This mutation is designed to prevent activation by WNK isoforms. Flp-mediated recombination removed the neo cassette. (J:191566)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stk39 Mutation: 42 strains or lines available

References

• Original: J:191566 Rafiqi FH, et al., Role of the WNK-activated SPAK kinase in regulating blood pressure. EMBO Mol Med. 2010 Feb;2(2):63-75
• All: 8 reference(s)