Optc^tm1.1Pnb
Targeted Allele Detail

Summary

• Symbol: Optc^tm1.1Pnb
• Name: opticin; targeted mutation 1.1, Paul N Bishop
• MGI ID: MGI:5462239
• Gene: Optc Location: Chr1:133824937-133835737 bp, - strand Genetic Position: Chr1, 58.02 cM
• Alliance: Optc^tm1.1Pnb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:191528
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 through part of exon 4 was replaced with a floxed neo cassette. Cre-mediated recombination removed the neo cassette. Western blot analysis confirmed the absence of protein expression in the eye. (J:191528)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Optc Mutation: 43 strains or lines available

References

• Original: J:191528 Le Goff MM, et al., The vitreous glycoprotein opticin inhibits preretinal neovascularization. Invest Ophthalmol Vis Sci. 2012 Jan;53(1):228-34
• All: 3 reference(s)